1-(5-Cyclopropyl-3-methylpyridin-2-yl)piperazine → HCID 71252125, compound

HRID 2411718Notes

Reaction equation

HRID 2411718 reaction equation
[CH3:1][C:2]1([CH3:19])[CH2:6][N:5]([C:7]2[CH:17]=[CH:16][C:10]([C:11]([O:13]CC)=O)=[CH:9][CH:8]=2)[C:4](=[O:18])[CH2:3]1.[CH:20]1([C:23]2[CH:24]=[C:25]([CH3:35])[C:26]([N:29]3[CH2:34][CH2:33][NH:32][CH2:31][CH2:30]3)=[N:27][CH:28]=2)[CH2:22][CH2:21]1>>[CH:20]1([C:23]2[CH:24]=[C:25]([CH3:35])[C:26]([N:29]3[CH2:30][CH2:31][N:32]([C:11]([C:10]4[CH:9]=[CH:8][C:7]([N:5]5[CH2:6][C:2]([CH3:1])([CH3:19])[CH2:3][C:4]5=[O:18])=[CH:17][CH:16]=4)=[O:13])[CH2:33][CH2:34]3)=[N:27][CH:28]=2)[CH2:22][CH2:21]1

Participants

3

Reactant 2

HCID 584847181-(5-Cyclopropyl-3-methylpyridin-2-yl)piperazineHCID 71252759HCID 71252759, compound

Product 1

HCID 71252125HCID 71252125, compoundYield 14.8%

Procedure

Using ethyl 4-(4,4-dimethyl-2-oxopyrrolidin-1-yl)benzoate (131 mg) described in Preparation Example 49 and 1-(5-cyclopropyl-3-methylpyridin-2-yl)piperazine (109 mg) described in Preparation Example 83 and by the reaction and treatment in the same manner as in Example 109, the title compound (32 mg) was obtained.

Workup

  1. customdescribed in Preparation Example 83 and by the reaction and treatment in the same manner as in Example 109

Sources & evidence

ORD record
ord-33c8a8b0e8f04a7aa7dd283f92f5114c
Source dataset
uspto-grants-2014_08
Patent number
US08816079B2

Reaction notes

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