5-Methyl-2-pyrrolidone → 3-{2-[4-(3,5-Dimethylpyridin-2-yl)piperazine-1-carbonyl]-5-(2-methyl-5-oxopyrrolidin-1-yl)phenyl}oxazolidin-2-one

HRID 2411719Notes

Reaction equation

HRID 2411719 reaction equation
Cl[C:2]1[CH:3]=[CH:4][C:5]([C:14]([N:16]2[CH2:21][CH2:20][N:19]([C:22]3[C:27]([CH3:28])=[CH:26][C:25]([CH3:29])=[CH:24][N:23]=3)[CH2:18][CH2:17]2)=[O:15])=[C:6]([N:8]2[CH2:12][CH2:11][O:10][C:9]2=[O:13])[CH:7]=1.[CH3:30][CH:31]1[NH:35][C:34](=[O:36])[CH2:33][CH2:32]1>>[CH3:28][C:27]1[C:22]([N:19]2[CH2:20][CH2:21][N:16]([C:14]([C:5]3[CH:4]=[CH:3][C:2]([N:35]4[C:34](=[O:36])[CH2:33][CH2:32][CH:31]4[CH3:30])=[CH:7][C:6]=3[N:8]3[CH2:12][CH2:11][O:10][C:9]3=[O:13])=[O:15])[CH2:17][CH2:18]2)=[N:23][CH:24]=[C:25]([CH3:29])[CH:26]=1

Participants

3

Reactant 2

HCID 660555-Methyl-2-pyrrolidoneHCID 547552343-{5-Chloro-2-[4-(3,5-dimethylpyridin-2-yl)piperazine-1-carbonyl]phenyl}oxazolidin-2-one

Product 1

HCID 712529953-{2-[4-(3,5-Dimethylpyridin-2-yl)piperazine-1-carbonyl]-5-(2-methyl-5-oxopyrrolidin-1-yl)phenyl}oxazolidin-2-oneYield 21%

Procedure

Using 3-{5-chloro-2-[4-(3,5-dimethylpyridin-2-yl)piperazine-1-carbonyl]phenyl}oxazolidin-2-one (207 mg) described in Preparation Example 168 and 5-methylpyrrolidin-2-one (50 mg) and by the reaction and treatment in the same manner as in Example 352, the title compound (50 mg) was obtained.

Sources & evidence

ORD record
ord-3f788cf333c34d5caeb4c069a7f8d7b1
Source dataset
uspto-grants-2014_08
Patent number
US08816079B2

Reaction notes

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