5,5-Dimethylpyrrolidin-2-one → HCID 71252137, compound

HRID 2411720Notes

Reaction equation

HRID 2411720 reaction equation
[CH3:1][C:2]1[C:3]([N:9]2[CH2:14][CH2:13][N:12]([C:15]([C:17]3[CH:22]=[CH:21][C:20](I)=[CH:19][CH:18]=3)=[O:16])[CH2:11][CH2:10]2)=[N:4][CH:5]=[C:6]([CH3:8])[CH:7]=1.[CH3:24][C:25]1([CH3:31])[NH:29][C:28](=[O:30])[CH2:27][CH2:26]1>>[CH3:1][C:2]1[C:3]([N:9]2[CH2:14][CH2:13][N:12]([C:15]([C:17]3[CH:22]=[CH:21][C:20]([N:29]4[C:25]([CH3:31])([CH3:24])[CH2:26][CH2:27][C:28]4=[O:30])=[CH:19][CH:18]=3)=[O:16])[CH2:11][CH2:10]2)=[N:4][CH:5]=[C:6]([CH3:8])[CH:7]=1

Participants

3

Reactant 2

HCID 111262105,5-Dimethylpyrrolidin-2-oneHCID 58484535[4-(3,5-Dimethylpyridin-2-yl)piperazin-1-yl](4-iodophenyl)methanone

Product 1

HCID 71252137HCID 71252137, compoundYield 18%

Procedure

Using [4-(3,5-dimethylpyridin-2-yl)piperazin-1-yl](4-iodophenyl)methanone (295 mg) described in Preparation Example 113 and 5,5-dimethylpyrrolidin-2-one (79 mg) and by the reaction and treatment in the same manner as in Example 1, the title compound (51 mg) was obtained.

Sources & evidence

ORD record
ord-8df68b28a2214e62ac18176d0924be28
Source dataset
uspto-grants-2014_08
Patent number
US08816079B2

Reaction notes

Loading…