HuagongsheHuagongshe Chemistry Print Report · For research reference only
2-Pyrrolidone → 1,1'-(4-{[4-(3,5-Dimethylpyridin-2-yl)piperazin-1-yl]carbonyl}-1,3-phenylene)dipyrrolidin-2-one
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 2-Pyrrolidone | HCID 12025 | — |
| Reactant | 1-{5-Chloro-2-[4-(3,5-dimethylpyridin-2-yl)piperazine-1-carbonyl]phenyl}pyrrolidin-2-one | HCID 58484698 | — |
| Product | 1,1'-(4-{[4-(3,5-Dimethylpyridin-2-yl)piperazin-1-yl]carbonyl}-1,3-phenylene)dipyrrolidin-2-one | HCID 71252228 | 31.7% |
Reaction Steps
Using 1-{5-chloro-2-[4-(3,5-dimethylpyridin-2-yl)piperazine-1-carbonyl]phenyl}pyrrolidin-2-one (206 mg) described in Preparation Example 169 and pyrrolidin-2-one (43 mg) and by the reaction and treatment in the same manner as in Example 352, the title compound (73 mg) was obtained.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08816079B2 |
| Source dataset | uspto-grants-2014_08 |
| ORD ID | ord-b608304ec9a643f0a6bc47ee351c1c1b |
| Source note | uspto-grants-2014_08 |