Ether hydrochloride → 1-{5-[4-(5-Cyclopropyl-3-methylpyridin-2-yl)piperazine-1-carbonyl]-4-methylpyridin-2-yl}pyrrolidin-2-one dihydrochloride

HRID 2411724Notes

Reaction equation

HRID 2411724 reaction equation
[CH:1]1([C:4]2[CH:5]=[C:6]([CH3:31])[C:7]([N:10]3[CH2:15][CH2:14][N:13]([C:16]([C:18]4[C:19]([CH3:30])=[CH:20][C:21]([N:24]5[CH2:28][CH2:27][CH2:26][C:25]5=[O:29])=[N:22][CH:23]=4)=[O:17])[CH2:12][CH2:11]3)=[N:8][CH:9]=2)[CH2:3][CH2:2]1.[ClH:32].C(OCC)C>ClCCl>[ClH:32].[ClH:32].[CH:1]1([C:4]2[CH:5]=[C:6]([CH3:31])[C:7]([N:10]3[CH2:11][CH2:12][N:13]([C:16]([C:18]4[C:19]([CH3:30])=[CH:20][C:21]([N:24]5[CH2:28][CH2:27][CH2:26][C:25]5=[O:29])=[N:22][CH:23]=4)=[O:17])[CH2:14][CH2:15]3)=[N:8][CH:9]=2)[CH2:2][CH2:3]1

Participants

4

Reactant 2

HCID 10953452Ether hydrochlorideHCID 712519061-{5-[4-(5-Cyclopropyl-3-methylpyridin-2-yl)piperazine-1-carbonyl]-4-methylpyridin-2-yl}pyrrolidin-2-one

Product 1

HCID 866767871-{5-[4-(5-Cyclopropyl-3-methylpyridin-2-yl)piperazine-1-carbonyl]-4-methylpyridin-2-yl}pyrrolidin-2-one dihydrochloride

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

Under a nitrogen stream, sodium hydride (47 mg) was suspended in N,N-dimethylformamide (10 mL), pyrrolidin-2-one (74 μL) was added, and the mixture was stirred at room temperature. Then, a solution of [4-(5-cyclopropyl-3-methylpyridin-2-yl)piperazin-1-yl](6-fluoro-4-methylpyridin-3-yl)methanone (210 mg) described in Preparation Example 140 in N,N-dimethylformamide (5 mL) was added, and the mixture was stirred at 95° C. The reaction mixture was cooled, water was added, and the mixture was extracted with ethyl acetate. The organic layer was washed with water and saturated brine, and the solvent was evaporated. The obtained residue was purified by column chromatography to give 1-{5-[4-(5-cyclopropyl-3-methylpyridin-2-yl)piperazine-1-carbonyl]-4-methylpyridin-2-yl}pyrrolidin-2-one. The obtained 1-{5-[4-(5-cyclopropyl-3-methylpyridin-2-yl)piperazine-1-carbonyl]-4-methylpyridin-2-yl}pyrrolidin-2-one was dissolved in dichloromethane, 1N hydrogen chloride/diethyl ether (5 mL) was added, and the precipitate was collected by filtration to give the title compound (12 mg).

Workup

  1. filtrationthe precipitate was collected by filtration

Sources & evidence

ORD record
ord-7eb5514b702b47169ecce78526efc93c
Source dataset
uspto-grants-2014_08
Patent number
US08816079B2

Reaction notes

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