2-Pyrrolidone → 1-{5-[4-(3,5-Dicyclopropylpyridin-2-yl)piperazine-1-carbonyl]pyridin-2-yl}pyrrolidin-2-one

HRID 2411725Notes

Reaction equation

HRID 2411725 reaction equation
Br[C:2]1[N:7]=[CH:6][C:5]([C:8]([N:10]2[CH2:15][CH2:14][N:13]([C:16]3[C:21]([CH:22]4[CH2:24][CH2:23]4)=[CH:20][C:19]([CH:25]4[CH2:27][CH2:26]4)=[CH:18][N:17]=3)[CH2:12][CH2:11]2)=[O:9])=[CH:4][CH:3]=1.[NH:28]1[CH2:32][CH2:31][CH2:30][C:29]1=[O:33]>>[CH:22]1([C:21]2[C:16]([N:13]3[CH2:14][CH2:15][N:10]([C:8]([C:5]4[CH:4]=[CH:3][C:2]([N:28]5[CH2:32][CH2:31][CH2:30][C:29]5=[O:33])=[N:7][CH:6]=4)=[O:9])[CH2:11][CH2:12]3)=[N:17][CH:18]=[C:19]([CH:25]3[CH2:27][CH2:26]3)[CH:20]=2)[CH2:24][CH2:23]1

Participants

3

Reactant 2

HCID 120252-PyrrolidoneHCID 58484777(6-Bromopyridin-3-yl)[4-(3,5-dicyclopropylpyridin-2-yl)piperazin-1-yl]methanone

Product 1

HCID 712523511-{5-[4-(3,5-Dicyclopropylpyridin-2-yl)piperazine-1-carbonyl]pyridin-2-yl}pyrrolidin-2-one

Procedure

Using (6-bromopyridin-3-yl)[4-(3,5-dicyclopropylpyridin-2-yl)piperazin-1-yl]methanone (510 mg) described in Preparation Example 143 and pyrrolidin-2-one (131 μL) and by the reaction and treatment in the same manner as in Example 1, the title compound (297 mg) was obtained.

Sources & evidence

ORD record
ord-37ff531775304ce7832419366e54f2dd
Source dataset
uspto-grants-2014_08
Patent number
US08816079B2

Reaction notes

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