2-Pyrrolidone → 1-{5-[4-(3,5-Dicyclopropylpyridin-2-yl)piperazine-1-carbonyl]-4-methylpyridin-2-yl}pyrrolidin-2-one

HRID 2411727Notes

Reaction equation

HRID 2411727 reaction equation
[NH:1]1[CH2:5][CH2:4][CH2:3][C:2]1=[O:6].[CH:7]1([C:10]2[C:11]([N:19]3[CH2:24][CH2:23][N:22]([C:25]([C:27]4[CH:28]=[N:29][C:30](F)=[CH:31][C:32]=4[CH3:33])=[O:26])[CH2:21][CH2:20]3)=[N:12][CH:13]=[C:14]([CH:16]3[CH2:18][CH2:17]3)[CH:15]=2)[CH2:9][CH2:8]1>>[CH:7]1([C:10]2[C:11]([N:19]3[CH2:20][CH2:21][N:22]([C:25]([C:27]4[C:32]([CH3:33])=[CH:31][C:30]([N:1]5[CH2:5][CH2:4][CH2:3][C:2]5=[O:6])=[N:29][CH:28]=4)=[O:26])[CH2:23][CH2:24]3)=[N:12][CH:13]=[C:14]([CH:16]3[CH2:18][CH2:17]3)[CH:15]=2)[CH2:8][CH2:9]1

Participants

3

Reactant 2

HCID 120252-PyrrolidoneHCID 58484583[4-(3,5-Dicyclopropylpyridin-2-yl)piperazin-1-yl](6-fluoro-4-methylpyridin-3-yl)methanone

Product 1

HCID 712521621-{5-[4-(3,5-Dicyclopropylpyridin-2-yl)piperazine-1-carbonyl]-4-methylpyridin-2-yl}pyrrolidin-2-one

Procedure

Using pyrrolidin-2-one (326 μL) and [4-(3,5-dicyclopropylpyridin-2-yl)piperazin-1-yl](6-fluoro-4-methylpyridin-3-yl)methanone (400 mg) described in Preparation Example 174 and by the reaction and treatment in the same manner as in Example 323, the title compound (187 mg) was obtained.

Workup

  1. customdescribed in Preparation Example 174 and by the reaction and treatment in the same manner as in Example 323

Sources & evidence

ORD record
ord-7773fb8d25254b649fb9c9e9e1be985f
Source dataset
uspto-grants-2014_08
Patent number
US08816079B2

Reaction notes

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