1-(5-Cyclopropyl-3-methylpyridin-2-yl)piperazine → HCID 71251907, compound

HRID 2411729Notes

Reaction equation

HRID 2411729 reaction equation
[O:1]=[S:2]1(=[O:23])[CH2:6][CH2:5][CH2:4][N:3]1[C:7]1[CH:16]=[CH:15][C:10]([C:11](OC)=[O:12])=[C:9]([N:17]2[CH2:21][CH2:20][CH2:19][C:18]2=[O:22])[CH:8]=1.[CH:24]1([C:27]2[CH:28]=[C:29]([CH3:39])[C:30]([N:33]3[CH2:38][CH2:37][NH:36][CH2:35][CH2:34]3)=[N:31][CH:32]=2)[CH2:26][CH2:25]1>>[CH:24]1([C:27]2[CH:28]=[C:29]([CH3:39])[C:30]([N:33]3[CH2:34][CH2:35][N:36]([C:11]([C:10]4[CH:15]=[CH:16][C:7]([N:3]5[CH2:4][CH2:5][CH2:6][S:2]5(=[O:1])=[O:23])=[CH:8][C:9]=4[N:17]4[CH2:21][CH2:20][CH2:19][C:18]4=[O:22])=[O:12])[CH2:37][CH2:38]3)=[N:31][CH:32]=2)[CH2:26][CH2:25]1

Participants

3

Reactant 2

HCID 584847181-(5-Cyclopropyl-3-methylpyridin-2-yl)piperazineHCID 71252731HCID 71252731, compound

Product 1

HCID 71251907HCID 71251907, compoundYield 4.1%

Procedure

Using methyl 4-(1,1-dioxo-1λ6-isothiazolidin-2-yl)-2-(2-oxopyrrolidin-1-yl)benzoate (131 mg) described in Preparation Example 33 and 1-(5-cyclopropyl-3-methylpyridin-2-yl)piperazine (84 mg) described in Preparation Example 83 and by the reaction and treatment in the same manner as in Example 109, the title compound (8.3 mg) was obtained.

Workup

  1. customdescribed in Preparation Example 83 and by the reaction and treatment in the same manner as in Example 109

Sources & evidence

ORD record
ord-23a9c6d3192b446d8f6226147da3fc95
Source dataset
uspto-grants-2014_08
Patent number
US08816079B2

Reaction notes

Loading…