2-Chloro-N,N-dimethylethylamine → HCID 59586569, compound

HRID 241173Notes

Reaction equation

HRID 241173 reaction equation
[CH3:1][C:2]1[NH:6][C:5]2[CH:7]=[C:8]([C:11]3[CH:12]=[CH:13][C:14]4[O:20][CH2:19][CH2:18][N:17]([C:21]5[C:30]6[C:25](=[C:26]([O:39][CH3:40])[C:27]([O:31][CH2:32][C:33]7C=CC=CC=7)=[CH:28][CH:29]=6)[N:24]=[CH:23][N:22]=5)[CH2:16][C:15]=4[CH:41]=3)[CH:9]=[CH:10][C:4]=2[N:3]=1.[CH3:42][N:43](CCCl)[CH3:44]>>[CH3:42][N:43]([CH3:44])[CH2:33][CH2:32][O:31][C:27]1[C:26]([O:39][CH3:40])=[C:25]2[C:30]([C:21]([N:17]3[CH2:16][C:15]4[CH:41]=[C:11]([C:8]5[CH:9]=[CH:10][C:4]6[N:3]=[C:2]([CH3:1])[NH:6][C:5]=6[CH:7]=5)[CH:12]=[CH:13][C:14]=4[O:20][CH2:19][CH2:18]3)=[N:22][CH:23]=[N:24]2)=[CH:29][CH:28]=1

Participants

3

Reactant 2

HCID 79012-Chloro-N,N-dimethylethylamineHCID 59586620HCID 59586620, compound

Product 1

HCID 59586569HCID 59586569, compound

Procedure

Synthesized according to the method of example 10 using 7-(2-methyl-1H-benzimidazol-6-yl)-4-{8-(methyloxy)-7-[(phenylmethyl)oxy]quinazolin-4-yl}-2,3,4,5-tetrahydro-1,4-benzoxazepine (example 1) in step 1 and 2-(N,N-dimethylamino)-1-chloroethane in step 2. 1H NMR (400 MHz, d6-DMSO): 8.57 (s, 1H), 7.93 (s, 1H), 7.82 (m, 3H), 7.59 (d, 1H), 7.51 (d, 1H), 7.01 (d, 1H), 7.01 (d, 1H), 5.38 (br s, 2H), 4.61 (m, 4H), 4.45 (br s, 2H), 3.95 (br s, 2H), 3.72 (t, 2H), 2.90 (s, 6H), 2.77 (s, 3H); MS (EI) for C30H32N6O3: 525 (MH+).

Workup

  1. customSynthesized

Sources & evidence

ORD record
ord-d36e2a6214dd46379029f0cbeee68e55
Source dataset
uspto-grants-2014_02
Patent number
US08648066B2

Reaction notes

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