HuagongsheHuagongshe Chemistry Print Report · For research reference only
2-Pyrrolidinone, 4-hydroxy-, (4S)- → (S)-1-{4-[4-(2,4-dimethylphenyl)piperazine-1-carbonyl]phenyl}-4-hydroxypyrrolidin-2-one
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 2-Pyrrolidinone, 4-hydroxy-, (4S)- | HCID 155084 | — |
| Reactant | (4-Bromophenyl)[4-(2,4-dimethylphenyl)piperazin-1-yl]methanone | HCID 58484623 | — |
| Product | (S)-1-{4-[4-(2,4-dimethylphenyl)piperazine-1-carbonyl]phenyl}-4-hydroxypyrrolidin-2-one | HCID 71252641 | 38.6% |
Reaction Steps
Using (4-bromophenyl) [4-(2,4-dimethylphenyl)piperazin-1-yl]methanone (1.87 g) described in Preparation Example 170 and (S)-4-hydroxypyrrolidin-2-one (556 mg) and by the reaction and treatment in the same manner as in Example 1, the title compound (760 mg) was obtained.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08816079B2 |
| Source dataset | uspto-grants-2014_08 |
| ORD ID | ord-d1d0c736e0464e6bb4cd221f5829f2b9 |
| Source note | uspto-grants-2014_08 |