HuagongsheHuagongshe Chemistry Print Report · For research reference only
2-Azabicyclo(2.2.1)hept-5-en-3-one → 2-{4-[4-(2,4-Dimethylphenyl)piperazine-1-carbonyl]phenyl}-2-azabicyclo[2.2.1]hept-5-en-3-one
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 2-Azabicyclo(2.2.1)hept-5-en-3-one | HCID 548678 | — |
| Reactant | (4-Bromophenyl)[4-(2,4-dimethylphenyl)piperazin-1-yl]methanone | HCID 58484623 | — |
| Product | 2-{4-[4-(2,4-Dimethylphenyl)piperazine-1-carbonyl]phenyl}-2-azabicyclo[2.2.1]hept-5-en-3-one | HCID 71251976 | 15.1% |
Reaction Steps
Using (4-bromophenyl)[4-(2,4-dimethylphenyl)piperazin-1-yl]methanone (747 mg) described in Preparation Example 170 and 2-azabicyclo[2.2.1]hept-5-en-3-one (218 mg) and by the reaction and treatment in the same manner as in Example 1, the title compound (121 mg) was obtained.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08816079B2 |
| Source dataset | uspto-grants-2014_08 |
| ORD ID | ord-627250b91ad1431badb1f34ed599255e |
| Source note | uspto-grants-2014_08 |