2-Pyrrolidone → HCID 71252485, compound

HRID 2411733Notes

Reaction equation

HRID 2411733 reaction equation
Br[C:2]1[CH:7]=[C:6]([F:8])[C:5]([C:9]([N:11]2[CH2:16][CH2:15][N:14]([C:17]3[CH:22]=[CH:21][C:20]([CH3:23])=[CH:19][C:18]=3[CH3:24])[CH2:13][CH2:12]2)=[O:10])=[C:4]([F:25])[CH:3]=1.[NH:26]1[CH2:30][CH2:29][CH2:28][C:27]1=[O:31]>>[CH3:24][C:18]1[CH:19]=[C:20]([CH3:23])[CH:21]=[CH:22][C:17]=1[N:14]1[CH2:15][CH2:16][N:11]([C:9]([C:5]2[C:6]([F:8])=[CH:7][C:2]([N:26]3[CH2:30][CH2:29][CH2:28][C:27]3=[O:31])=[CH:3][C:4]=2[F:25])=[O:10])[CH2:12][CH2:13]1

Participants

3

Reactant 2

HCID 120252-PyrrolidoneHCID 58484529HCID 58484529, compound

Product 1

HCID 71252485HCID 71252485, compound

Procedure

Using (4-bromo-2,6-difluorophenyl)[4-(2,4-dimethylphenyl)piperazin-1-yl]methanone (819 mg) described in Preparation Example 109 and pyrrolidin-2-one (0.16 mL) and by the reaction and treatment in the same manner as in Example 1, the title compound (49 mg) was obtained.

Sources & evidence

ORD record
ord-10c85bb4e16b46b0874f0ed9c0112c53
Source dataset
uspto-grants-2014_08
Patent number
US08816079B2

Reaction notes

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