2-Azaspiro(4.5)decan-3-one → 2-{4-[4-(2,4-Dimethylphenyl)piperazine-1-carbonyl]phenyl}-2-azaspiro[4.5]decan-3-one

HRID 2411735Notes

Reaction equation

HRID 2411735 reaction equation
Br[C:2]1[CH:7]=[CH:6][C:5]([C:8]([N:10]2[CH2:15][CH2:14][N:13]([C:16]3[CH:21]=[CH:20][C:19]([CH3:22])=[CH:18][C:17]=3[CH3:23])[CH2:12][CH2:11]2)=[O:9])=[CH:4][CH:3]=1.[CH2:24]1[C:28]2([CH2:33][CH2:32][CH2:31][CH2:30][CH2:29]2)[CH2:27][C:26](=[O:34])[NH:25]1>>[CH3:23][C:17]1[CH:18]=[C:19]([CH3:22])[CH:20]=[CH:21][C:16]=1[N:13]1[CH2:14][CH2:15][N:10]([C:8]([C:5]2[CH:6]=[CH:7][C:2]([N:25]3[C:26](=[O:34])[CH2:27][C:28]4([CH2:33][CH2:32][CH2:31][CH2:30][CH2:29]4)[CH2:24]3)=[CH:3][CH:4]=2)=[O:9])[CH2:11][CH2:12]1

Participants

3

Reactant 2

HCID 474572-Azaspiro(4.5)decan-3-oneHCID 58484623(4-Bromophenyl)[4-(2,4-dimethylphenyl)piperazin-1-yl]methanone

Product 1

HCID 712529992-{4-[4-(2,4-Dimethylphenyl)piperazine-1-carbonyl]phenyl}-2-azaspiro[4.5]decan-3-oneYield 14.7%

Procedure

Using (4-bromophenyl) [4-(2,4-dimethylphenyl)piperazin-1-yl]methanone (747 mg) described in Preparation Example 170 and 2-azaspiro[4.5]decan-3-one (306 mg) and by the reaction and treatment in the same manner as in Example 1, the title compound (131 mg) was obtained.

Sources & evidence

ORD record
ord-900a1b1eac774a929fe1a27d92d86e9f
Source dataset
uspto-grants-2014_08
Patent number
US08816079B2

Reaction notes

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