5-(Hydroxymethyl)pyrrolidin-2-one → HCID 71251851, compound

HRID 2411738Notes

Reaction equation

HRID 2411738 reaction equation
Br[C:2]1[CH:7]=[CH:6][C:5]([C:8]([N:10]2[CH2:15][CH2:14][N:13]([C:16]3[CH:21]=[CH:20][C:19]([CH3:22])=[CH:18][C:17]=3[CH3:23])[CH2:12][CH2:11]2)=[O:9])=[C:4]([S:24]([CH3:27])(=[O:26])=[O:25])[CH:3]=1.[OH:28][CH2:29][CH:30]1[NH:34][C:33](=[O:35])[CH2:32][CH2:31]1>>[CH3:23][C:17]1[CH:18]=[C:19]([CH3:22])[CH:20]=[CH:21][C:16]=1[N:13]1[CH2:14][CH2:15][N:10]([C:8]([C:5]2[CH:6]=[CH:7][C:2]([N:34]3[C@H:30]([CH2:29][OH:28])[CH2:31][CH2:32][C:33]3=[O:35])=[CH:3][C:4]=2[S:24]([CH3:27])(=[O:26])=[O:25])=[O:9])[CH2:11][CH2:12]1

Participants

3

Reactant 2

HCID 5583595-(Hydroxymethyl)pyrrolidin-2-oneHCID 58484856(4-Bromo-2-methanesulfonylphenyl)[4-(2,4-dimethylphenyl)piperazin-1-yl]methanone

Product 1

HCID 71251851HCID 71251851, compoundYield 50.1%

Procedure

Using (4-bromo-2-methanesulfonylphenyl)[4-(2,4-dimethylphenyl)piperazin-1-yl]methanone (903 mg) described in Preparation Example 110 and 5-hydroxymethylpyrrolidin-2-one (230 mg) and by the reaction and treatment in the same manner as in Example 1, the title compound (486 mg) was obtained.

Sources & evidence

ORD record
ord-8c22d241bb294f6f8fb6ec7e1e99f58a
Source dataset
uspto-grants-2014_08
Patent number
US08816079B2

Reaction notes

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