2-Pyrrolidone → HCID 71252601, compound

HRID 2411744Notes

Reaction equation

HRID 2411744 reaction equation
[CH3:1][C:2]1[C:3]([N:9]2[CH2:14][CH2:13][N:12]([C:15]([C:17]3[CH:22]=[CH:21][C:20](I)=[CH:19][CH:18]=3)=[O:16])[CH2:11][CH2:10]2)=[N:4][CH:5]=[C:6]([CH3:8])[CH:7]=1.[NH:24]1[CH2:28][CH2:27][CH2:26][C:25]1=[O:29]>>[CH3:1][C:2]1[C:3]([N:9]2[CH2:14][CH2:13][N:12]([C:15]([C:17]3[CH:22]=[CH:21][C:20]([N:24]4[CH2:28][CH2:27][CH2:26][C:25]4=[O:29])=[CH:19][CH:18]=3)=[O:16])[CH2:11][CH2:10]2)=[N:4][CH:5]=[C:6]([CH3:8])[CH:7]=1

Participants

3

Reactant 2

HCID 120252-PyrrolidoneHCID 58484535[4-(3,5-Dimethylpyridin-2-yl)piperazin-1-yl](4-iodophenyl)methanone

Product 1

HCID 71252601HCID 71252601, compound

Procedure

Using [4-(3,5-dimethylpyridin-2-yl)piperazin-1-yl](4-iodophenyl)methanone (568 mg) described in Preparation Example 113 and pyrrolidin-2-one (0.12 mL) and by the reaction and treatment in the same manner as in Example 1, the title compound (427 mg) was obtained.

Sources & evidence

ORD record
ord-ce0a869451394e00889d5d8324ed8c97
Source dataset
uspto-grants-2014_08
Patent number
US08816079B2

Reaction notes

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