1-(3,5-Dimethylpyridin-2-yl)piperazine → HCID 71253021, compound

HRID 2411745Notes

Reaction equation

HRID 2411745 reaction equation
[CH3:1][CH:2]1[CH2:6][CH2:5][C:4](=[O:7])[N:3]1[C:8]1[CH:16]=[CH:15][C:11]([C:12]([OH:14])=O)=[CH:10][CH:9]=1.[CH3:17][C:18]1[C:19]([N:25]2[CH2:30][CH2:29][NH:28][CH2:27][CH2:26]2)=[N:20][CH:21]=[C:22]([CH3:24])[CH:23]=1>>[CH3:17][C:18]1[C:19]([N:25]2[CH2:26][CH2:27][N:28]([C:12]([C:11]3[CH:10]=[CH:9][C:8]([N:3]4[CH:2]([CH3:1])[CH2:6][CH2:5][C:4]4=[O:7])=[CH:16][CH:15]=3)=[O:14])[CH2:29][CH2:30]2)=[N:20][CH:21]=[C:22]([CH3:24])[CH:23]=1

Participants

3

Reactant 2

HCID 584844961-(3,5-Dimethylpyridin-2-yl)piperazineHCID 71252478HCID 71252478, compound

Product 1

HCID 71253021HCID 71253021, compoundYield 51.8%

Procedure

Using 4-(2-methyl-5-oxopyrrolidin-1-yl)benzoic acid (438 mg) described in Preparation Example 50 and 1-(3,5-dimethylpyridin-2-yl)piperazine (383 mg) described in Preparation Example 79 and by the reaction and treatment in the same manner as in Example 93, the title compound (406 mg) was obtained.

Workup

  1. customdescribed in Preparation Example 79 and by the reaction and treatment in the same manner as in Example 93

Sources & evidence

ORD record
ord-3c884e783d82429fa3664f066b82eff0
Source dataset
uspto-grants-2014_08
Patent number
US08816079B2

Reaction notes

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