1-(2,4-Xylyl)piperazine → HCID 71261384, compound

HRID 2411751Notes

Reaction equation

HRID 2411751 reaction equation
[O:1]=[C:2]1[CH2:7][CH2:6][CH2:5][CH2:4][N:3]1[C:8]1[CH:18]=[CH:17][C:11]([C:12]([O:14]CC)=O)=[CH:10][CH:9]=1.[CH3:19][C:20]1[CH:25]=[C:24]([CH3:26])[CH:23]=[CH:22][C:21]=1[N:27]1[CH2:32][CH2:31][NH:30][CH2:29][CH2:28]1>>[CH3:19][C:20]1[CH:25]=[C:24]([CH3:26])[CH:23]=[CH:22][C:21]=1[N:27]1[CH2:28][CH2:29][N:30]([C:12]([C:11]2[CH:10]=[CH:9][C:8]([N:3]3[CH2:4][CH2:5][CH2:6][CH2:7][C:2]3=[O:1])=[CH:18][CH:17]=2)=[O:14])[CH2:31][CH2:32]1

Participants

3

Reactant 2

HCID 705441-(2,4-Xylyl)piperazineHCID 52562672HCID 52562672, compound

Product 1

HCID 71261384HCID 71261384, compoundYield 56%

Procedure

Using ethyl 4-(2-oxopiperidin-1-yl)benzoate (247 mg) and 1-(2,4-dimethylphenyl)piperazine (190 mg) and by the reaction and treatment in the same manner as in Example 109, the title compound (219 mg) was obtained.

Workup

  1. customby the reaction and treatment in the same manner as in Example 109

Sources & evidence

ORD record
ord-67ed98d1178243c2abca73e860776d75
Source dataset
uspto-grants-2014_08
Patent number
US08816079B2

Reaction notes

Loading…