N-Acetylimidazolidinone → HCID 71252331, compound

HRID 2411753Notes

Reaction equation

[C:1]([N:4]1[CH2:8][CH2:7][NH:6][C:5]1=[O:9])(=[O:3])[CH3:2].Br[C:11]1[CH:12]=[CH:13][C:14]([C:17]([N:19]2[CH2:24][CH2:23][N:22]([C:25]3[CH:30]=[CH:29][C:28]([CH3:31])=[CH:27][C:26]=3[CH3:32])[CH2:21][CH2:20]2)=[O:18])=[N:15][CH:16]=1>>[C:1]([N:4]1[CH2:8][CH2:7][N:6]([C:11]2[CH:16]=[N:15][C:14]([C:17]([N:19]3[CH2:20][CH2:21][N:22]([C:25]4[CH:30]=[CH:29][C:28]([CH3:31])=[CH:27][C:26]=4[CH3:32])[CH2:23][CH2:24]3)=[O:18])=[CH:13][CH:12]=2)[C:5]1=[O:9])(=[O:3])[CH3:2]

Participants

Reactant 2

HCID 79350N-Acetylimidazolidinone

HCID 58484574HCID 58484574, compound

Product 1

HCID 71252331HCID 71252331, compoundYield 36.8%

Procedure

Using 1-acetyl-2-imidazolidinone (128 mg) and (5-bromopyridin-2-yl)[4-(2,4-dimethylphenyl)piperazin-1-yl]methanone (374 mg) described in Preparation Example 137 and by the reaction and treatment in the same manner as in Example 1, the title compound (155 mg) was obtained.

Workup

customdescribed in Preparation Example 137 and by the reaction and treatment in the same manner as in Example 1

Sources & evidence

ORD record: ord-8759d70e940e4e1f8855de88af3950db
Source dataset: uspto-grants-2014_08
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US08816079B2

Reaction notes

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