1-Methylimidazolidin-2-one → HCID 71251874, compound

HRID 2411754Notes

Reaction equation

HRID 2411754 reaction equation
[CH3:1][N:2]1[CH2:6][CH2:5][NH:4][C:3]1=[O:7].Br[C:9]1[CH:10]=[CH:11][C:12]([C:15]([N:17]2[CH2:22][CH2:21][N:20]([C:23]3[CH:28]=[CH:27][C:26]([CH3:29])=[CH:25][C:24]=3[CH3:30])[CH2:19][CH2:18]2)=[O:16])=[N:13][CH:14]=1>>[CH3:30][C:24]1[CH:25]=[C:26]([CH3:29])[CH:27]=[CH:28][C:23]=1[N:20]1[CH2:21][CH2:22][N:17]([C:15]([C:12]2[N:13]=[CH:14][C:9]([N:4]3[CH2:5][CH2:6][N:2]([CH3:1])[C:3]3=[O:7])=[CH:10][CH:11]=2)=[O:16])[CH2:18][CH2:19]1

Participants

3

Reactant 2

HCID 5676001-Methylimidazolidin-2-oneHCID 58484574HCID 58484574, compound

Product 1

HCID 71251874HCID 71251874, compoundYield 53.6%

Procedure

Using 1-methyl-2-imidazolidinone (37 mg) and (5-bromopyridin-2-yl)[4-(2,4-dimethylphenyl)piperazin-1-yl]methanone (140 mg) described in Preparation Example 137 and by the reaction and treatment in the same manner as in Example 1, the title compound (78 mg) was obtained.

Workup

  1. customdescribed in Preparation Example 137 and by the reaction and treatment in the same manner as in Example 1

Sources & evidence

ORD record
ord-8c1250d23a19427b917b9a622b0e2327
Source dataset
uspto-grants-2014_08
Patent number
US08816079B2

Reaction notes

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