1-Methylimidazolidin-2-one → HCID 71252600, compound

HRID 2411755Notes

Reaction equation

HRID 2411755 reaction equation
[CH3:1][N:2]1[CH2:6][CH2:5][NH:4][C:3]1=[O:7].Br[C:9]1[CH:10]=[CH:11][C:12]([C:15]([N:17]2[CH2:22][CH2:21][N:20]([C:23]3[C:28]([CH3:29])=[CH:27][C:26]([CH3:30])=[CH:25][N:24]=3)[CH2:19][CH2:18]2)=[O:16])=[N:13][CH:14]=1>>[CH3:29][C:28]1[C:23]([N:20]2[CH2:21][CH2:22][N:17]([C:15]([C:12]3[N:13]=[CH:14][C:9]([N:4]4[CH2:5][CH2:6][N:2]([CH3:1])[C:3]4=[O:7])=[CH:10][CH:11]=3)=[O:16])[CH2:18][CH2:19]2)=[N:24][CH:25]=[C:26]([CH3:30])[CH:27]=1

Participants

3

Reactant 2

HCID 5676001-Methylimidazolidin-2-oneHCID 58484566HCID 58484566, compound

Product 1

HCID 71252600HCID 71252600, compoundYield 62.3%

Procedure

Using 1-methyl-2-imidazolidinone (53 mg) and (5-bromopyridin-2-yl)[4-(3,5-dimethylpyridin-2-yl)piperazin-1-yl]methanone (200 mg) described in Preparation Example 134 and by the reaction and treatment in the same manner as in Example 1, the title compound (130 mg) was obtained.

Workup

  1. customdescribed in Preparation Example 134 and by the reaction and treatment in the same manner as in Example 1

Sources & evidence

ORD record
ord-54d3bb0d0fdb4ee2a7b1b7bfe2a5bdd5
Source dataset
uspto-grants-2014_08
Patent number
US08816079B2

Reaction notes

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