Methanol → HCID 71252852, compound

Participants

Reaction Steps

To a mixture of 1-acetyl-3-{6-[4-(2,4-dimethylphenyl)piperazine-1-carbonyl]pyridin-3-yl}imidazolidin-2-one (70 mg) described in Example 388 and potassium carbonate (35 mg) was added methanol (5 mL), and the mixture was stirred with heating under reflux for 1 hr. Water was added to the reaction mixture, and the mixture was extracted with ethyl acetate. The organic layer was washed with saturated brine, and the solvent was evaporated. The obtained residue was purified by column chromatography (chloroform:methanol) to give the title compound (23 mg).

Provenance & Evidence