N-Acetylimidazolidinone → HCID 71252311, compound

HRID 2411757Notes

Reaction equation

[C:1]([N:4]1[CH2:8][CH2:7][NH:6][C:5]1=[O:9])(=[O:3])[CH3:2].Br[C:11]1[CH:12]=[CH:13][C:14]([C:17]([N:19]2[CH2:24][CH2:23][N:22]([C:25]3[C:30]([CH3:31])=[CH:29][C:28]([CH:32]4[CH2:34][CH2:33]4)=[CH:27][N:26]=3)[CH2:21][CH2:20]2)=[O:18])=[N:15][CH:16]=1>>[C:1]([N:4]1[CH2:8][CH2:7][N:6]([C:11]2[CH:16]=[N:15][C:14]([C:17]([N:19]3[CH2:24][CH2:23][N:22]([C:25]4[C:30]([CH3:31])=[CH:29][C:28]([CH:32]5[CH2:34][CH2:33]5)=[CH:27][N:26]=4)[CH2:21][CH2:20]3)=[O:18])=[CH:13][CH:12]=2)[C:5]1=[O:9])(=[O:3])[CH3:2]

Participants

Reactant 2

HCID 79350N-Acetylimidazolidinone

HCID 58484818HCID 58484818, compound

Product 1

HCID 71252311HCID 71252311, compoundYield 11.5%

Procedure

Using 1-acetyl-2-imidazolidinone (316 mg) and (5-bromopyridin-2-yl)[4-(5-cyclopropyl-3-methylpyridin-2-yl)piperazin-1-yl]methanone (900 mg) described in Preparation Example 135 and by the reaction and treatment in the same manner as in Example 1, the title compound (116 mg) was obtained.

Workup

customdescribed in Preparation Example 135 and by the reaction and treatment in the same manner as in Example 1

Sources & evidence

ORD record: ord-5aaa2a451bce44b0a7d7167fdd45dcc7
Source dataset: uspto-grants-2014_08
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US08816079B2

Reaction notes

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