Methyl iodide → HCID 71252208, compound

HRID 2411758Notes

Reaction equation

[CH:1]1([C:4]2[CH:5]=[C:6]([CH3:30])[C:7]([N:10]3[CH2:15][CH2:14][N:13]([C:16]([C:18]4[N:23]=[CH:22][C:21]([N:24]5[CH2:28][CH2:27][NH:26][C:25]5=[O:29])=[CH:20][CH:19]=4)=[O:17])[CH2:12][CH2:11]3)=[N:8][CH:9]=2)[CH2:3][CH2:2]1.[CH3:31]I>>[CH:1]1([C:4]2[CH:5]=[C:6]([CH3:30])[C:7]([N:10]3[CH2:11][CH2:12][N:13]([C:16]([C:18]4[N:23]=[CH:22][C:21]([N:24]5[CH2:28][CH2:27][N:26]([CH3:31])[C:25]5=[O:29])=[CH:20][CH:19]=4)=[O:17])[CH2:14][CH2:15]3)=[N:8][CH:9]=2)[CH2:2][CH2:3]1

Participants

Reactant 2

HCID 6328Methyl iodide

HCID 71252457HCID 71252457, compound

Product 1

HCID 71252208HCID 71252208, compound

Procedure

Using 1-{6-[4-(5-cyclopropyl-3-methylpyridin-2-yl)piperazine-1-carbonyl]pyridin-3-yl}imidazolidin-2-one (280 mg) described in Example 393 and methyl iodide (51 μL) and by the reaction and treatment in the same manner as in Example 36, the title compound (211 mg) was obtained.

Sources & evidence

ORD record: ord-d7b10149930b4729907e4b1f9d3d4269
Source dataset: uspto-grants-2014_08
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US08816079B2

Reaction notes

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