N-Acetylimidazolidinone → HCID 71251929, compound

HRID 2411759Notes

Reaction equation

[C:1]([N:4]1[CH2:8][CH2:7][NH:6][C:5]1=[O:9])(=[O:3])[CH3:2].Br[C:11]1[CH:12]=[CH:13][C:14]([C:17]([N:19]2[CH2:24][CH2:23][N:22]([C:25]3[C:30]([CH3:31])=[CH:29][C:28]([CH3:32])=[C:27]([CH3:33])[N:26]=3)[CH2:21][CH2:20]2)=[O:18])=[N:15][CH:16]=1>>[C:1]([N:4]1[CH2:8][CH2:7][N:6]([C:11]2[CH:16]=[N:15][C:14]([C:17]([N:19]3[CH2:24][CH2:23][N:22]([C:25]4[C:30]([CH3:31])=[CH:29][C:28]([CH3:32])=[C:27]([CH3:33])[N:26]=4)[CH2:21][CH2:20]3)=[O:18])=[CH:13][CH:12]=2)[C:5]1=[O:9])(=[O:3])[CH3:2]

Participants

Reactant 2

HCID 79350N-Acetylimidazolidinone

HCID 71251982HCID 71251982, compound

Product 1

HCID 71251929HCID 71251929, compoundYield 53.2%

Procedure

Using 1-acetyl-2-imidazolidinone (655 mg) and (5-bromopyridin-2-yl)[4-(3,5,6-trimethylpyridin-2-yl)piperazin-1-yl]methanone (1.81 g) described in Preparation Example 147 and by the reaction and treatment in the same manner as in Example 1, the title compound (1.08 g) was obtained.

Workup

customdescribed in Preparation Example 147 and by the reaction and treatment in the same manner as in Example 1

Sources & evidence

ORD record: ord-7737fc0e06b342c2a298fcf958408110
Source dataset: uspto-grants-2014_08
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US08816079B2

Reaction notes

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