N-Acetylimidazolidinone → HCID 71252675, compound

HRID 2411760Notes

Reaction equation

[C:1]([N:4]1[CH2:8][CH2:7][NH:6][C:5]1=[O:9])(=[O:3])[CH3:2].Br[C:11]1[CH:12]=[CH:13][C:14]([C:17]([N:19]2[CH2:24][CH2:23][N:22]([C:25]3[C:30]([CH:31]4[CH2:33][CH2:32]4)=[CH:29][C:28]([CH:34]4[CH2:36][CH2:35]4)=[CH:27][N:26]=3)[CH2:21][CH2:20]2)=[O:18])=[N:15][CH:16]=1>>[C:1]([N:4]1[CH2:8][CH2:7][N:6]([C:11]2[CH:16]=[N:15][C:14]([C:17]([N:19]3[CH2:24][CH2:23][N:22]([C:25]4[C:30]([CH:31]5[CH2:33][CH2:32]5)=[CH:29][C:28]([CH:34]5[CH2:35][CH2:36]5)=[CH:27][N:26]=4)[CH2:21][CH2:20]3)=[O:18])=[CH:13][CH:12]=2)[C:5]1=[O:9])(=[O:3])[CH3:2]

Participants

Reactant 2

HCID 79350N-Acetylimidazolidinone

HCID 71252484HCID 71252484, compound

Product 1

HCID 71252675HCID 71252675, compoundYield 12.8%

Procedure

Using 1-acetyl-2-imidazolidinone (462 mg) and (5-bromopyridin-2-yl)[4-(3,5-dicyclopropylpyridin-2-yl)piperazin-1-yl]methanone (1.4 g) described in Preparation Example 142 and by the reaction and treatment in the same manner as in Example 1, the title compound (199 mg) was obtained.

Workup

customdescribed in Preparation Example 142 and by the reaction and treatment in the same manner as in Example 1

Sources & evidence

ORD record: ord-743943f950b1448bbad48506095a3ebe
Source dataset: uspto-grants-2014_08
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US08816079B2

Reaction notes

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