Methyl iodide → HCID 71252000, compound

HRID 2411761Notes

Reaction equation

[CH3:1][C:2]1[C:3]([N:10]2[CH2:15][CH2:14][N:13]([C:16]([C:18]3[N:23]=[CH:22][C:21]([N:24]4[CH2:28][CH2:27][NH:26][C:25]4=[O:29])=[CH:20][CH:19]=3)=[O:17])[CH2:12][CH2:11]2)=[N:4][C:5]([CH3:9])=[C:6]([CH3:8])[CH:7]=1.[CH3:30]I>>[CH3:30][N:26]1[CH2:27][CH2:28][N:24]([C:21]2[CH:22]=[N:23][C:18]([C:16]([N:13]3[CH2:12][CH2:11][N:10]([C:3]4[C:2]([CH3:1])=[CH:7][C:6]([CH3:8])=[C:5]([CH3:9])[N:4]=4)[CH2:15][CH2:14]3)=[O:17])=[CH:19][CH:20]=2)[C:25]1=[O:29]

Participants

Reactant 2

HCID 6328Methyl iodide

HCID 71253048HCID 71253048, compound

Product 1

HCID 71252000HCID 71252000, compound

Procedure

Using 1-{6-[4-(3,5,6-trimethylpyridin-2-yl)piperazine-1-carbonyl]pyridin-3-yl}imidazolidin-2-one (136 mg) described in Example 397 and methyl iodide (26 μL) and by the reaction and treatment in the same manner as in Example 36, the title compound (109 mg) was obtained.

Sources & evidence

ORD record: ord-f3682e2105b140cca538eb8d18383e33
Source dataset: uspto-grants-2014_08
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US08816079B2

Reaction notes

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