1-Methylimidazolidin-2-one → HCID 71252891, compound

HRID 2411762Notes

Reaction equation

HRID 2411762 reaction equation
[CH3:1][N:2]1[CH2:6][CH2:5][NH:4][C:3]1=[O:7].Br[C:9]1[CH:10]=[CH:11][C:12]([C:15]([N:17]2[CH2:22][CH2:21][N:20]([C:23]3[C:28]([CH:29]4[CH2:31][CH2:30]4)=[CH:27][C:26]([CH:32]4[CH2:34][CH2:33]4)=[CH:25][N:24]=3)[CH2:19][CH2:18]2)=[O:16])=[N:13][CH:14]=1>>[CH:29]1([C:28]2[C:23]([N:20]3[CH2:21][CH2:22][N:17]([C:15]([C:12]4[N:13]=[CH:14][C:9]([N:4]5[CH2:5][CH2:6][N:2]([CH3:1])[C:3]5=[O:7])=[CH:10][CH:11]=4)=[O:16])[CH2:18][CH2:19]3)=[N:24][CH:25]=[C:26]([CH:32]3[CH2:34][CH2:33]3)[CH:27]=2)[CH2:31][CH2:30]1

Participants

3

Reactant 2

HCID 5676001-Methylimidazolidin-2-oneHCID 71252484HCID 71252484, compound

Product 1

HCID 71252891HCID 71252891, compoundYield 34.6%

Procedure

Using 1-methyl-2-imidazolidinone (181 mg) and (5-bromopyridin-2-yl)[4-(3,5-dicyclopropylpyridin-2-yl)piperazin-1-yl]methanone (700 mg) described in Preparation Example 142 and by the reaction and treatment in the same manner as in Example 1, the title compound (253 mg) was obtained.

Workup

  1. customdescribed in Preparation Example 142 and by the reaction and treatment in the same manner as in Example 1

Sources & evidence

ORD record
ord-d5e203e1f14045089497588df688ff4d
Source dataset
uspto-grants-2014_08
Patent number
US08816079B2

Reaction notes

Loading…