1-(2,4-Xylyl)piperazine → HCID 71252851, compound

HRID 2411763Notes

Reaction equation

HRID 2411763 reaction equation
C([N:4]1[CH2:8][CH2:7][N:6]([C:9]2[CH:18]=[CH:17][C:12]([C:13]([O:15]C)=O)=[CH:11][CH:10]=2)[C:5]1=[O:19])(=O)C.[CH3:20][C:21]1[CH:26]=[C:25]([CH3:27])[CH:24]=[CH:23][C:22]=1[N:28]1[CH2:33][CH2:32][NH:31][CH2:30][CH2:29]1>>[CH3:20][C:21]1[CH:26]=[C:25]([CH3:27])[CH:24]=[CH:23][C:22]=1[N:28]1[CH2:29][CH2:30][N:31]([C:13]([C:12]2[CH:11]=[CH:10][C:9]([N:6]3[CH2:7][CH2:8][NH:4][C:5]3=[O:19])=[CH:18][CH:17]=2)=[O:15])[CH2:32][CH2:33]1

Participants

3

Reactant 2

HCID 705441-(2,4-Xylyl)piperazineHCID 71252328HCID 71252328, compound

Product 1

HCID 71252851HCID 71252851, compoundYield 45.3%

Procedure

Using methyl 4-(3-acetyl-2-oxoimidazolidin-1-yl)benzoate (290 mg) described in Preparation Example 59 and 1-(2,4-dimethylphenyl)piperazine (209 mg) and by the reaction and treatment in the same manner as in Example 109, the title compound (188.5 mg) was obtained.

Sources & evidence

ORD record
ord-66f5391b78fe45c7a860aa0ee75aae93
Source dataset
uspto-grants-2014_08
Patent number
US08816079B2

Reaction notes

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