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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 2411769Generated: November 1, 2026

1-Methylimidazolidin-2-one → 1-{4-[4-(5-Cyclopropyl-3-methylpyridin-2-yl)piperazine-1-carbonyl]phenyl}-3-methylimidazolidin-2-one

https://huagongshe.com/reaction/2411769

Reaction equation

Participants

RoleNameHCIDCharge
Reactant1-Methylimidazolidin-2-oneHCID 567600—
Reactant(4-Bromophenyl)[4-(5-cyclopropyl-3-methylpyridin-2-yl)piperazin-1-yl]methanoneHCID 71252330—
Product1-{4-[4-(5-Cyclopropyl-3-methylpyridin-2-yl)piperazine-1-carbonyl]phenyl}-3-methylimidazolidin-2-oneHCID 712525349.5%

Reaction Steps

Using (4-bromophenyl)[4-(5-cyclopropyl-3-methylpyridin-2-yl)piperazin-1-yl]methanone (240 mg) described in Preparation Example 185 and 1-methylimidazolidin-2-one (90 mg) and by the reaction and treatment in the same manner as in Example 1, the title compound (24 mg) was obtained.

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS08816079B2
Source datasetuspto-grants-2014_08
ORD IDord-ef935891d1a84d669161d58442ca5e5f
Source noteuspto-grants-2014_08