HRID2411785

反应详情

EQUATION

反应方程式

REACTANTS

反应物

结构：Cc1cnc(N2CCN(C(=O)c3ccc(Br)nc3)CC2)c(C)c1

HCID58484661

未命名化合物

HCID71252673

未命名化合物

PRODUCTS

生成物

结构：Cc1cnc(N2CCN(C(=O)c3ccc(N4C(=O)NCC4(C)C)nc3)CC2)c(C)c1

HCID71252026

未命名化合物

结构：COc1ccc(CN2CC(C)(C)N(c3ccc(C(=O)N4CCN(c5ncc(C)cc5C)CC4)cn3)C2=O)cc1

HCID71252182

未命名化合物

PROCEDURE

实验过程

Using (6-bromopyridin-3-yl)[4-(3,5-dimethylpyridin-2-yl)piperazin-1-yl]methanone (150 mg) described in Preparation Example 127 and 1-(4-methoxybenzyl)-4,4-dimethylimidazolidin-2-one (112 mg) described in Preparation Example 54 and by the reaction and treatment in the same manner as in Example 426, the title compound (56 mg) was obtained via 3-{5-[4-(3,5-dimethylpyridin-2-yl)piperazine-1-carbonyl]pyridin-2-yl}-1-(4-methoxybenzyl)-4,4-dimethylimidazolidin-2-one (119 mg).

WORKUP

后处理

customdescribed in Preparation Example 54 and by the reaction and treatment in the same manner as in Example 426

来源与证据

来源类型: Open Reaction Database
ORD 记录: ord-b085cb32ddad4008b6aa11ad3ea18362
来源数据集: uspto-grants-2014_08
DOI: 10.6084/m9.figshare.5104873.v1
专利: US08816079B2
来源说明: uspto-grants-2014_08

反应 SMILES

Br[C:2]1[N:7]=[CH:6][C:5]([C:8]([N:10]2[CH2:15][CH2:14][N:13]([C:16]3[C:21]([CH3:22])=[CH:20][C:19]([CH3:23])=[CH:18][N:17]=3)[CH2:12][CH2:11]2)=[O:9])=[CH:4][CH:3]=1.[CH3:24][O:25][C:26]1[CH:40]=[CH:39][C:29]([CH2:30][N:31]2[CH2:35][C:34]([CH3:37])([CH3:36])[NH:33][C:32]2=[O:38])=[CH:28][CH:27]=1>>[CH3:22][C:21]1[C:16]([N:13]2[CH2:14][CH2:15][N:10]([C:8]([C:5]3[CH:4]=[CH:3][C:2]([N:33]4[C:34]([CH3:37])([CH3:36])[CH2:35][NH:31][C:32]4=[O:38])=[N:7][CH:6]=3)=[O:9])[CH2:11][CH2:12]2)=[N:17][CH:18]=[C:19]([CH3:23])[CH:20]=1.[CH3:22][C:21]1[C:16]([N:13]2[CH2:14][CH2:15][N:10]([C:8]([C:5]3[CH:4]=[CH:3][C:2]([N:33]4[C:34]([CH3:37])([CH3:36])[CH2:35][N:31]([CH2:30][C:29]5[CH:39]=[CH:40][C:26]([O:25][CH3:24])=[CH:27][CH:28]=5)[C:32]4=[O:38])=[N:7][CH:6]=3)=[O:9])[CH2:11][CH2:12]2)=[N:17][CH:18]=[C:19]([CH3:23])[CH:20]=1