(4-Bromophenyl)[4-(3,5-dimethylpyridin-2-yl)piperazin-1-yl]methanone → 3-Benzoyl-1-{4-[4-(3,5-dimethylpyridin-2-yl)piperazine-1-carbonyl]phenyl}-4-methylimidazolidin-2-one

HRID 2411786Notes

Reaction equation

HRID 2411786 reaction equation
Br[C:2]1[CH:7]=[CH:6][C:5]([C:8]([N:10]2[CH2:15][CH2:14][N:13]([C:16]3[C:21]([CH3:22])=[CH:20][C:19]([CH3:23])=[CH:18][N:17]=3)[CH2:12][CH2:11]2)=[O:9])=[CH:4][CH:3]=1.[C:24]([N:32]1[CH:36]([CH3:37])[CH2:35][NH:34][C:33]1=[O:38])(=[O:31])[C:25]1[CH:30]=[CH:29][CH:28]=[CH:27][CH:26]=1>>[C:24]([N:32]1[CH:36]([CH3:37])[CH2:35][N:34]([C:2]2[CH:7]=[CH:6][C:5]([C:8]([N:10]3[CH2:15][CH2:14][N:13]([C:16]4[C:21]([CH3:22])=[CH:20][C:19]([CH3:23])=[CH:18][N:17]=4)[CH2:12][CH2:11]3)=[O:9])=[CH:4][CH:3]=2)[C:33]1=[O:38])(=[O:31])[C:25]1[CH:26]=[CH:27][CH:28]=[CH:29][CH:30]=1

Participants

3

Reactant 2

HCID 71252046(4-Bromophenyl)[4-(3,5-dimethylpyridin-2-yl)piperazin-1-yl]methanoneHCID 712527551-Benzoyl-5-methylimidazolidin-2-one

Product 1

HCID 712522043-Benzoyl-1-{4-[4-(3,5-dimethylpyridin-2-yl)piperazine-1-carbonyl]phenyl}-4-methylimidazolidin-2-oneYield 16%

Procedure

Using (4-bromophenyl) [4-(3,5-dimethylpyridin-2-yl)piperazin-1-yl]methanone (150 mg) described in Preparation Example 165 and 1-benzoyl-5-methylimidazolidin-2-one (98 mg) described in Preparation Example 56 and by the reaction and treatment in the same manner as in Example 1, the title compound (32 mg) was obtained.

Workup

  1. customdescribed in Preparation Example 56 and by the reaction and treatment in the same manner as in Example 1

Sources & evidence

ORD record
ord-c43c039e67e443b9bb87234bbb2d01bd
Source dataset
uspto-grants-2014_08
Patent number
US08816079B2

Reaction notes

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