HRID2411787

反应详情

EQUATION

反应方程式

REACTANTS

反应物

结构：Cc1cnc(N2CCN(C(=O)c3ccc(Br)cc3)CC2)c(C)c1

HCID71252046

未命名化合物

HCID71252113

未命名化合物

PRODUCTS

生成物

结构：Cc1cnc(N2CCN(C(=O)c3ccc(N4CC(C)(C)N(C(=O)c5ccccc5)C4=O)cc3)CC2)c(C)c1

HCID71252486

未命名化合物

收率 56.1%

PROCEDURE

实验过程

Using (4-bromophenyl)[4-(3,5-dimethylpyridin-2-yl)piperazin-1-yl]methanone (150 mg) described in Preparation Example 165 and 1-benzoyl-5,5-dimethylimidazolidin-2-one (105 mg) described in Preparation Example 58 and by the reaction and treatment in the same manner as in Example 1, the title compound (115 mg) was obtained.

WORKUP

后处理

customdescribed in Preparation Example 58 and by the reaction and treatment in the same manner as in Example 1

来源与证据

来源类型: Open Reaction Database
ORD 记录: ord-844bee25ff1f490fa8ca2fdd1f4f10a7
来源数据集: uspto-grants-2014_08
DOI: 10.6084/m9.figshare.5104873.v1
专利: US08816079B2
来源说明: uspto-grants-2014_08

反应 SMILES

Br[C:2]1[CH:7]=[CH:6][C:5]([C:8]([N:10]2[CH2:15][CH2:14][N:13]([C:16]3[C:21]([CH3:22])=[CH:20][C:19]([CH3:23])=[CH:18][N:17]=3)[CH2:12][CH2:11]2)=[O:9])=[CH:4][CH:3]=1.[C:24]([N:32]1[C:36]([CH3:38])([CH3:37])[CH2:35][NH:34][C:33]1=[O:39])(=[O:31])[C:25]1[CH:30]=[CH:29][CH:28]=[CH:27][CH:26]=1>>[C:24]([N:32]1[C:36]([CH3:37])([CH3:38])[CH2:35][N:34]([C:2]2[CH:7]=[CH:6][C:5]([C:8]([N:10]3[CH2:15][CH2:14][N:13]([C:16]4[C:21]([CH3:22])=[CH:20][C:19]([CH3:23])=[CH:18][N:17]=4)[CH2:12][CH2:11]3)=[O:9])=[CH:4][CH:3]=2)[C:33]1=[O:39])(=[O:31])[C:25]1[CH:26]=[CH:27][CH:28]=[CH:29][CH:30]=1