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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 2411796Generated: October 25, 2026

N-Acetylimidazolidinone → 5-(3-Acetyl-2-oxoimidazolidin-1-yl)-2-[4-(3,5,6-trimethylpyridin-2-yl)piperazine-1-carbonyl]benzonitrile

https://huagongshe.com/reaction/2411796

Reaction equation

Participants

RoleNameHCIDCharge
ReactantN-AcetylimidazolidinoneHCID 79350—
Reactant5-Bromo-2-[4-(3,5,6-trimethylpyridin-2-yl)piperazine-1-carbonyl]benzonitrileHCID 71252174—
Product5-(3-Acetyl-2-oxoimidazolidin-1-yl)-2-[4-(3,5,6-trimethylpyridin-2-yl)piperazine-1-carbonyl]benzonitrileHCID 7125211782.5%

Reaction Steps

Using 5-bromo-2-[4-(3,5,6-trimethylpyridin-2-yl)piperazine-1-carbonyl]benzonitrile (1.24 g) described in Preparation Example 172 and 1-acetylimidazolidin-2-one (461 mg) and by the reaction and treatment in the same manner as in Example 1, the title compound (1.14 g) was obtained.

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS08816079B2
Source datasetuspto-grants-2014_08
ORD IDord-e5d452de18e444d3aeb64b376acb428c
Source noteuspto-grants-2014_08