1-(3,5-Dimethylpyridin-2-yl)piperazine → HCID 71251952, compound

HRID 2411797Notes

Reaction equation

HRID 2411797 reaction equation
[O:1]=[C:2]1[NH:7][CH2:6][CH2:5][CH2:4][N:3]1[C:8]1[CH:18]=[CH:17][C:11]([C:12]([O:14]CC)=O)=[CH:10][CH:9]=1.[CH3:19][C:20]1[C:21]([N:27]2[CH2:32][CH2:31][NH:30][CH2:29][CH2:28]2)=[N:22][CH:23]=[C:24]([CH3:26])[CH:25]=1>>[CH3:19][C:20]1[C:21]([N:27]2[CH2:28][CH2:29][N:30]([C:12]([C:11]3[CH:10]=[CH:9][C:8]([N:3]4[CH2:4][CH2:5][CH2:6][NH:7][C:2]4=[O:1])=[CH:18][CH:17]=3)=[O:14])[CH2:31][CH2:32]2)=[N:22][CH:23]=[C:24]([CH3:26])[CH:25]=1

Participants

3

Reactant 2

HCID 584844961-(3,5-Dimethylpyridin-2-yl)piperazineHCID 71252167HCID 71252167, compound

Product 1

HCID 71251952HCID 71251952, compoundYield 77.4%

Procedure

Using ethyl 4-(2-oxotetrahydropyrimidin-1-yl)benzoate (84 mg) described in Preparation Example 60 and 1-(3,5-dimethylpyridin-2-yl)piperazine (65 mg) described in Preparation Example 79 and by the reaction and treatment in the same manner as in Example 109, the title compound (103 mg) was obtained.

Workup

  1. customdescribed in Preparation Example 79 and by the reaction and treatment in the same manner as in Example 109

Sources & evidence

ORD record
ord-9e4ee17e5c814364b7b73e44a55329a6
Source dataset
uspto-grants-2014_08
Patent number
US08816079B2

Reaction notes

Loading…