Methyl iodide → HCID 71252421, compound

HRID 2411798Notes

Reaction equation

[CH3:1][C:2]1[C:3]([N:9]2[CH2:14][CH2:13][N:12]([C:15]([C:17]3[CH:22]=[CH:21][C:20]([N:23]4[CH2:28][CH2:27][CH2:26][NH:25][C:24]4=[O:29])=[CH:19][CH:18]=3)=[O:16])[CH2:11][CH2:10]2)=[N:4][CH:5]=[C:6]([CH3:8])[CH:7]=1.[CH3:30]I>>[CH3:1][C:2]1[C:3]([N:9]2[CH2:10][CH2:11][N:12]([C:15]([C:17]3[CH:18]=[CH:19][C:20]([N:23]4[CH2:28][CH2:27][CH2:26][N:25]([CH3:30])[C:24]4=[O:29])=[CH:21][CH:22]=3)=[O:16])[CH2:13][CH2:14]2)=[N:4][CH:5]=[C:6]([CH3:8])[CH:7]=1

Participants

Reactant 2

HCID 6328Methyl iodide

HCID 71251952HCID 71251952, compound

Product 1

HCID 71252421HCID 71252421, compound

Procedure

Using 1-{4-[4-(3,5-dimethylpyridin-2-yl)piperazine-1-carbonyl]phenyl}tetrahydropyrimidin-2-one (78 mg) described in Example 446 and methyl iodide (14 μL) and by the reaction and treatment in the same manner as in Example 36, the title compound (49 mg) was obtained.

Sources & evidence

ORD record: ord-6ca64acae3bb49f297782dd2b61e3350
Source dataset: uspto-grants-2014_08
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US08816079B2

Reaction notes

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