Back
HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 2411799Generated: November 1, 2026

3-(4-Methoxybenzyl)-5-methylimidazolidine-2,4-dione → 1-{4-[4-(3,5-Dimethylpyridin-2-yl)piperazine-1-carbonyl]phenyl}-3-(4-methoxybenzyl)-5-methylimidazolidine-2,4-dione

https://huagongshe.com/reaction/2411799

Reaction equation

Participants

RoleNameHCIDCharge
Reactant3-(4-Methoxybenzyl)-5-methylimidazolidine-2,4-dioneHCID 68328356—
Reactant(4-Bromophenyl)[4-(3,5-dimethylpyridin-2-yl)piperazin-1-yl]methanoneHCID 71252046—
Product1-{4-[4-(3,5-Dimethylpyridin-2-yl)piperazine-1-carbonyl]phenyl}-3-(4-methoxybenzyl)-5-methylimidazolidine-2,4-dioneHCID 7125257386.5%

Reaction Steps

Using (4-bromophenyl)[4-(3,5-dimethylpyridin-2-yl)piperazin-1-yl]methanone (150 mg) described in Preparation Example 165 and 3-(4-methoxybenzyl)-5-methylimidazolidine-2,4-dione (141 mg) described in Preparation Example 51 and by the reaction and treatment in the same manner as in Example 1, the title compound (183 mg) was obtained.

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS08816079B2
Source datasetuspto-grants-2014_08
ORD IDord-5f30b1964f8c43a2a5c28d85cdaa3494
Source noteuspto-grants-2014_08