HuagongsheHuagongshe Chemistry Print Report · For research reference only
Methyl iodide → 1-{4-[4-(3,5-Dimethylpyridin-2-yl)piperazine-1-carbonyl]phenyl}-3,5-dimethylimidazolidine-2,4-dione
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Methyl iodide | HCID 6328 | — |
| Reactant | 1-{4-[4-(3,5-Dimethylpyridin-2-yl)piperazine-1-carbonyl]phenyl}-5-methylimidazolidine-2,4-dione | HCID 71252739 | — |
| Product | 1-{4-[4-(3,5-Dimethylpyridin-2-yl)piperazine-1-carbonyl]phenyl}-3,5-dimethylimidazolidine-2,4-dione | HCID 71252063 | — |
Reaction Steps
Using 1-{4-[4-(3,5-dimethylpyridin-2-yl)piperazine-1-carbonyl]phenyl}-5-methylimidazolidine-2,4-dione (50 mg) described in Example 450 and methyl iodide (9.2 μL) and by the reaction and treatment in the same manner as in Example 36, the title compound (26 mg) was obtained.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08816079B2 |
| Source dataset | uspto-grants-2014_08 |
| ORD ID | ord-6303aba16b424cc4b8b486d7c8123df4 |
| Source note | uspto-grants-2014_08 |