1-(3,5-Dimethylpyridin-2-yl)piperazine → HCID 71252700, compound

HRID 2411805Notes

Reaction equation

HRID 2411805 reaction equation
[O:1]=[C:2]1[N:6]([C:7]2([C:10]3[CH:19]=[CH:18][C:13]([C:14]([O:16]C)=O)=[CH:12][CH:11]=3)[CH2:9][CH2:8]2)[CH2:5][CH2:4][O:3]1.[CH3:20][C:21]1[C:22]([N:28]2[CH2:33][CH2:32][NH:31][CH2:30][CH2:29]2)=[N:23][CH:24]=[C:25]([CH3:27])[CH:26]=1>>[CH3:20][C:21]1[C:22]([N:28]2[CH2:29][CH2:30][N:31]([C:14]([C:13]3[CH:12]=[CH:11][C:10]([C:7]4([N:6]5[CH2:5][CH2:4][O:3][C:2]5=[O:1])[CH2:8][CH2:9]4)=[CH:19][CH:18]=3)=[O:16])[CH2:32][CH2:33]2)=[N:23][CH:24]=[C:25]([CH3:27])[CH:26]=1

Participants

3

Reactant 2

HCID 584844961-(3,5-Dimethylpyridin-2-yl)piperazineHCID 71252734HCID 71252734, compound

Product 1

HCID 71252700HCID 71252700, compoundYield 67%

Procedure

Using methyl 4-[1-(2-oxooxazolidin-3-yl)cyclopropyl]benzoate (52 mg) described in Preparation Example 69 and 1-(3,5-dimethylpyridin-2-yl)piperazine (38 mg) described in Preparation Example 79 and by the reaction and treatment in the same manner as in Example 109, the title compound (56 mg) was obtained.

Workup

  1. customdescribed in Preparation Example 79 and by the reaction and treatment in the same manner as in Example 109

Sources & evidence

ORD record
ord-645b967e6b5c4d0e999d793a3787fc6b
Source dataset
uspto-grants-2014_08
Patent number
US08816079B2

Reaction notes

Loading…