1-(3,5-Dimethylpyridin-2-yl)piperazine → HCID 71252339, compound

HRID 2411808Notes

Reaction equation

HRID 2411808 reaction equation
[CH3:1][C@H:2]1[CH2:6][O:5][C:4](=[O:7])[N:3]1[CH2:8][C:9]1[CH:17]=[CH:16][C:12]([C:13]([OH:15])=O)=[CH:11][CH:10]=1.[CH3:18][C:19]1[C:20]([N:26]2[CH2:31][CH2:30][NH:29][CH2:28][CH2:27]2)=[N:21][CH:22]=[C:23]([CH3:25])[CH:24]=1>>[CH3:18][C:19]1[C:20]([N:26]2[CH2:27][CH2:28][N:29]([C:13]([C:12]3[CH:11]=[CH:10][C:9]([CH2:8][N:3]4[C@@H:2]([CH3:1])[CH2:6][O:5][C:4]4=[O:7])=[CH:17][CH:16]=3)=[O:15])[CH2:30][CH2:31]2)=[N:21][CH:22]=[C:23]([CH3:25])[CH:24]=1

Participants

3

Reactant 2

HCID 584844961-(3,5-Dimethylpyridin-2-yl)piperazineHCID 71251949HCID 71251949, compound

Product 1

HCID 71252339HCID 71252339, compoundYield 95.6%

Procedure

Using (S)-4-(4-methyl-2-oxooxazolidin-3-ylmethyl)benzoic acid (141 mg) described in Preparation Example 66 and 1-(3,5-dimethylpyridin-2-yl)piperazine (126 mg) described in Preparation Example 79 and by the reaction and treatment in the same manner as in Example 87, the title compound (234 mg) was obtained.

Workup

  1. customdescribed in Preparation Example 79 and by the reaction and treatment in the same manner as in Example 87

Sources & evidence

ORD record
ord-10dca081d39848cdb5b8f04e3677de6c
Source dataset
uspto-grants-2014_08
Patent number
US08816079B2

Reaction notes

Loading…