1-(5-Cyclopropyl-3-methylpyridin-2-yl)piperazine → HCID 71252553, compound

HRID 2411809Notes

Reaction equation

HRID 2411809 reaction equation
[CH3:1][C@H:2]1[CH2:6][O:5][C:4](=[O:7])[N:3]1[CH2:8][C:9]1[CH:17]=[CH:16][C:12]([C:13]([OH:15])=O)=[CH:11][CH:10]=1.[CH:18]1([C:21]2[CH:22]=[C:23]([CH3:33])[C:24]([N:27]3[CH2:32][CH2:31][NH:30][CH2:29][CH2:28]3)=[N:25][CH:26]=2)[CH2:20][CH2:19]1>>[CH:18]1([C:21]2[CH:22]=[C:23]([CH3:33])[C:24]([N:27]3[CH2:28][CH2:29][N:30]([C:13]([C:12]4[CH:11]=[CH:10][C:9]([CH2:8][N:3]5[C@@H:2]([CH3:1])[CH2:6][O:5][C:4]5=[O:7])=[CH:17][CH:16]=4)=[O:15])[CH2:31][CH2:32]3)=[N:25][CH:26]=2)[CH2:20][CH2:19]1

Participants

3

Reactant 2

HCID 584847181-(5-Cyclopropyl-3-methylpyridin-2-yl)piperazineHCID 71251949HCID 71251949, compound

Product 1

HCID 71252553HCID 71252553, compoundYield 81.4%

Procedure

Using (S)-4-(4-methyl-2-oxooxazolidin-3-ylmethyl)benzoic acid (141 mg) described in Preparation Example 66 and 1-(5-cyclopropyl-3-methylpyridin-2-yl)piperazine (143 mg) described in Preparation Example 83 and by the reaction and treatment in the same manner as in Example 87, the title compound (212 mg) was obtained.

Workup

  1. customdescribed in Preparation Example 83 and by the reaction and treatment in the same manner as in Example 87

Sources & evidence

ORD record
ord-b368cf1944e740879195178cf1ee2ab6
Source dataset
uspto-grants-2014_08
Patent number
US08816079B2

Reaction notes

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