4-(2-Oxo-1,3-oxazinan-3-yl)benzoic acid → HCID 71252536, compound

HRID 2411810Notes

Reaction equation

HRID 2411810 reaction equation
[O:1]=[C:2]1[N:7]([C:8]2[CH:16]=[CH:15][C:11]([C:12]([OH:14])=O)=[CH:10][CH:9]=2)[CH2:6][CH2:5][CH2:4][O:3]1.[CH3:17][C:18]1[C:19]([N:25]2[CH2:30][CH2:29][NH:28][CH2:27][CH2:26]2)=[N:20][CH:21]=[C:22]([CH3:24])[CH:23]=1>>[CH3:17][C:18]1[C:19]([N:25]2[CH2:26][CH2:27][N:28]([C:12]([C:11]3[CH:10]=[CH:9][C:8]([N:7]4[CH2:6][CH2:5][CH2:4][O:3][C:2]4=[O:1])=[CH:16][CH:15]=3)=[O:14])[CH2:29][CH2:30]2)=[N:20][CH:21]=[C:22]([CH3:24])[CH:23]=1

Participants

3

Reactant 2

HCID 184531884-(2-Oxo-1,3-oxazinan-3-yl)benzoic acidHCID 584844961-(3,5-Dimethylpyridin-2-yl)piperazine

Product 1

HCID 71252536HCID 71252536, compoundYield 86.4%

Procedure

Using 4-(2-oxo[1,3]oxazinan-3-yl)benzoic acid (111 mg) and 1-(3,5-dimethylpyridin-2-yl)piperazine (96 mg) described in Preparation Example 79 and by the reaction and treatment in the same manner as in Example 87, the title compound (171 mg) was obtained.

Workup

  1. customdescribed in Preparation Example 79 and by the reaction and treatment in the same manner as in Example 87

Sources & evidence

ORD record
ord-96a89dd2aa58478991a95969a57c0659
Source dataset
uspto-grants-2014_08
Patent number
US08816079B2

Reaction notes

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