4-(2-Oxo-1,3-oxazinan-3-yl)benzoic acid → HCID 71252375, compound

HRID 2411811Notes

Reaction equation

HRID 2411811 reaction equation
[O:1]=[C:2]1[N:7]([C:8]2[CH:16]=[CH:15][C:11]([C:12]([OH:14])=O)=[CH:10][CH:9]=2)[CH2:6][CH2:5][CH2:4][O:3]1.[CH:17]1([C:20]2[CH:21]=[C:22]([CH3:32])[C:23]([N:26]3[CH2:31][CH2:30][NH:29][CH2:28][CH2:27]3)=[N:24][CH:25]=2)[CH2:19][CH2:18]1>>[CH:17]1([C:20]2[CH:21]=[C:22]([CH3:32])[C:23]([N:26]3[CH2:27][CH2:28][N:29]([C:12]([C:11]4[CH:10]=[CH:9][C:8]([N:7]5[CH2:6][CH2:5][CH2:4][O:3][C:2]5=[O:1])=[CH:16][CH:15]=4)=[O:14])[CH2:30][CH2:31]3)=[N:24][CH:25]=2)[CH2:19][CH2:18]1

Participants

3

Reactant 2

HCID 184531884-(2-Oxo-1,3-oxazinan-3-yl)benzoic acidHCID 584847181-(5-Cyclopropyl-3-methylpyridin-2-yl)piperazine

Product 1

HCID 71252375HCID 71252375, compoundYield 74.4%

Procedure

Using 4-(2-oxo[1,3]oxazinan-3-yl)benzoic acid (111 mg) and 1-(5-cyclopropyl-3-methylpyridin-2-yl)piperazine (109 mg) described in Preparation Example 83 and by the reaction and treatment in the same manner as in Example 87, the title compound (157 mg) was obtained.

Workup

  1. customdescribed in Preparation Example 83 and by the reaction and treatment in the same manner as in Example 87

Sources & evidence

ORD record
ord-51f43b93c9044135b97e7351f05234d5
Source dataset
uspto-grants-2014_08
Patent number
US08816079B2

Reaction notes

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