Methyl iodide → HCID 71252316, compound

HRID 2411813Notes

Reaction equation

[CH3:1][C:2]1[CH:7]=[C:6]([CH3:8])[CH:5]=[CH:4][C:3]=1[N:9]1[CH2:14][CH2:13][N:12]([C:15]([C:17]2[CH:22]=[CH:21][C:20]([NH:23][S:24]([CH3:27])(=[O:26])=[O:25])=[CH:19][CH:18]=2)=[O:16])[CH2:11][CH2:10]1.[CH3:28]I>>[CH3:1][C:2]1[CH:7]=[C:6]([CH3:8])[CH:5]=[CH:4][C:3]=1[N:9]1[CH2:14][CH2:13][N:12]([C:15]([C:17]2[CH:22]=[CH:21][C:20]([N:23]([CH3:28])[S:24]([CH3:27])(=[O:26])=[O:25])=[CH:19][CH:18]=2)=[O:16])[CH2:11][CH2:10]1

Participants

Reactant 2

HCID 6328Methyl iodide

HCID 39847681HCID 39847681, compound

Product 1

HCID 71252316HCID 71252316, compound

Procedure

Using N-{4-[4-(2,4-dimethylphenyl)piperazine-1-carbonyl]phenyl}methanesulfonamide (194 mg) described in Example 461 and methyl iodide (34 μL) and by the reaction and treatment in the same manner as in Example 36, the title compound (57 mg) was obtained.

Sources & evidence

ORD record: ord-8a9b3ff68a144eafac120f5882a4e876
Source dataset: uspto-grants-2014_08
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US08816079B2

Reaction notes

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