4-(Methylsulfonamido)benzoic acid → HCID 71252515, compound

HRID 2411816Notes

Reaction equation

HRID 2411816 reaction equation
[CH3:1][S:2]([NH:5][C:6]1[CH:14]=[CH:13][C:9]([C:10]([OH:12])=O)=[CH:8][CH:7]=1)(=[O:4])=[O:3].[Cl:15][C:16]1[C:17]([N:23]2[CH2:28][CH2:27][NH:26][CH2:25][CH2:24]2)=[N:18][CH:19]=[C:20]([Cl:22])[CH:21]=1>>[Cl:15][C:16]1[C:17]([N:23]2[CH2:28][CH2:27][N:26]([C:10]([C:9]3[CH:8]=[CH:7][C:6]([NH:5][S:2]([CH3:1])(=[O:3])=[O:4])=[CH:14][CH:13]=3)=[O:12])[CH2:25][CH2:24]2)=[N:18][CH:19]=[C:20]([Cl:22])[CH:21]=1

Participants

3

Reactant 2

HCID 2506534-(Methylsulfonamido)benzoic acidHCID 27714311-(3,5-Dichloropyridin-2-yl)piperazine

Product 1

HCID 71252515HCID 71252515, compoundYield 94.3%

Procedure

Using 4-methanesulfonylaminobenzoic acid (226 mg) and 1-(3,5-dichloropyridin-2-yl)piperazine (244 mg) and by the reaction and treatment in the same manner as in Example 87, N-{4-[4-(3,5-dichloropyridin-2-yl)piperazine-1-carbonyl]phenyl}methanesulfonamide (425 mg) was obtained. Using the obtained N-{4-[4-(3,5-dichloropyridin-2-yl)piperazine-1-carbonyl]phenyl}methanesulfonamide (425 mg) and methylboronic acid (504 mg) and by the reaction and treatment in the same manner as in Example 115, the title compound (91 mg) was obtained.

Workup

  1. customby the reaction and treatment in the same manner as in Example 87

Sources & evidence

ORD record
ord-6b82a432c95a4c1286a08bd087f72fed
Source dataset
uspto-grants-2014_08
Patent number
US08816079B2

Reaction notes

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