Methyl iodide → HCID 71252476, compound

HRID 2411817Notes

Reaction equation

HRID 2411817 reaction equation
[CH3:1][C:2]1[C:3]([N:9]2[CH2:14][CH2:13][N:12]([C:15]([C:17]3[CH:22]=[CH:21][C:20]([NH:23][S:24]([CH3:27])(=[O:26])=[O:25])=[CH:19][CH:18]=3)=[O:16])[CH2:11][CH2:10]2)=[N:4][CH:5]=[C:6]([CH3:8])[CH:7]=1.[CH3:28]I>>[CH3:1][C:2]1[C:3]([N:9]2[CH2:14][CH2:13][N:12]([C:15]([C:17]3[CH:22]=[CH:21][C:20]([N:23]([CH3:28])[S:24]([CH3:27])(=[O:26])=[O:25])=[CH:19][CH:18]=3)=[O:16])[CH2:11][CH2:10]2)=[N:4][CH:5]=[C:6]([CH3:8])[CH:7]=1

Participants

3

Reactant 2

HCID 6328Methyl iodideHCID 71252930HCID 71252930, compound

Product 1

HCID 71252476HCID 71252476, compound

Procedure

Using N-{4-[4-(3,5-dimethylpyridin-2-yl)piperazine-1-carbonyl]phenyl}methanesulfonamide (259.2 mg) described in Example 465 and methyl iodide (65 μL) and by the reaction and treatment in the same manner as in Example 36, the title compound (187 mg) was obtained.

Sources & evidence

ORD record
ord-fc6f01a7ff9040a5b951d7783cba0ff7
Source dataset
uspto-grants-2014_08
Patent number
US08816079B2

Reaction notes

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