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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 2411818Generated: November 3, 2026

4-{[(Methylsulfonyl)amino]methyl}benzoic acid → N-{4-[4-(3,5-dimethylpyridin-2-yl)piperazine-1-carbonyl]benzyl}methanesulfonamide

https://huagongshe.com/reaction/2411818

Reaction equation

Participants

RoleNameHCIDCharge
Reactant4-{[(Methylsulfonyl)amino]methyl}benzoic acidHCID 1506609—
Reactant1-(3,5-Dimethylpyridin-2-yl)piperazineHCID 58484496—
ProductN-{4-[4-(3,5-dimethylpyridin-2-yl)piperazine-1-carbonyl]benzyl}methanesulfonamideHCID 7125238080.9%

Reaction Steps

Using 4-(methanesulfonylaminomethyl)benzoic acid (183 mg) and 1-(3,5-dimethylpyridin-2-yl)piperazine (153 mg) described in Preparation Example 79 and by the reaction and treatment in the same manner as in Example 87, the title compound (260 mg) was obtained.

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS08816079B2
Source datasetuspto-grants-2014_08
ORD IDord-8cccdcc87e6644ce9ba0ebe0e8b498c8
Source noteuspto-grants-2014_08