Back
HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 2411819Generated: November 3, 2026

4-{[(Methylsulfonyl)amino]methyl}benzoic acid → N-{4-[4-(5-cyclopropyl-3-methylpyridin-2-yl)piperazine-1-carbonyl]benzyl}methanesulfonamide

https://huagongshe.com/reaction/2411819

Reaction equation

Participants

RoleNameHCIDCharge
Reactant4-{[(Methylsulfonyl)amino]methyl}benzoic acidHCID 1506609—
Reactant1-(5-Cyclopropyl-3-methylpyridin-2-yl)piperazineHCID 58484718—
ProductN-{4-[4-(5-cyclopropyl-3-methylpyridin-2-yl)piperazine-1-carbonyl]benzyl}methanesulfonamideHCID 7125286938.8%

Reaction Steps

Using 4-(methanesulfonylaminomethyl)benzoic acid (138 mg) and 1-(5-cyclopropyl-3-methylpyridin-2-yl)piperazine (156 mg) described in Preparation Example 83 and by the reaction and treatment in the same manner as in Example 87, the title compound (100 mg) was obtained.

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS08816079B2
Source datasetuspto-grants-2014_08
ORD IDord-339884548843464095c167f9fab46c6d
Source noteuspto-grants-2014_08