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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 2411821Generated: October 30, 2026

1-(5-Cyclopropyl-3-methylpyridin-2-yl)piperazine → N-(1-{4-[4-(5-cyclopropyl-3-methylpyridin-2-yl)piperazine-1-carbonyl]phenyl}-1-methylethyl)methanesulfonamide

https://huagongshe.com/reaction/2411821

Reaction equation

Participants

RoleNameHCIDCharge
Reactant1-(5-Cyclopropyl-3-methylpyridin-2-yl)piperazineHCID 58484718—
ReactantMethyl 4-(1-methanesulfonylamino-1-methylethyl)benzoateHCID 71252533—
ProductN-(1-{4-[4-(5-cyclopropyl-3-methylpyridin-2-yl)piperazine-1-carbonyl]phenyl}-1-methylethyl)methanesulfonamideHCID 7125226376.4%

Reaction Steps

Using methyl 4-(1-methanesulfonylamino-1-methylethyl)benzoate (126 mg) described in Preparation Example 71 and 1-(5-cyclopropyl-3-methylpyridin-2-yl)piperazine (101 mg) described in Preparation Example 83 and by the reaction and treatment in the same manner as in Example 109, the title compound (162 mg) was obtained.

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS08816079B2
Source datasetuspto-grants-2014_08
ORD IDord-3f1c9151f37744f3bc99e45f6316ad68
Source noteuspto-grants-2014_08