HCID 28286504, compound → HCID 71252880, compound

HRID 2411822Notes

Reaction equation

HRID 2411822 reaction equation
[CH3:1][S:2]([NH:5][C@H:6]([C:8]1[CH:16]=[CH:15][C:11]([C:12]([OH:14])=O)=[CH:10][CH:9]=1)[CH3:7])(=[O:4])=[O:3].[CH3:17][C:18]1[C:19]([N:25]2[CH2:30][CH2:29][NH:28][CH2:27][CH2:26]2)=[N:20][CH:21]=[C:22]([CH3:24])[CH:23]=1>>[CH3:17][C:18]1[C:19]([N:25]2[CH2:26][CH2:27][N:28]([C:12]([C:11]3[CH:10]=[CH:9][C:8]([C@@H:6]([NH:5][S:2]([CH3:1])(=[O:3])=[O:4])[CH3:7])=[CH:16][CH:15]=3)=[O:14])[CH2:29][CH2:30]2)=[N:20][CH:21]=[C:22]([CH3:24])[CH:23]=1

Participants

3

Reactant 2

HCID 28286504HCID 28286504, compoundHCID 584844961-(3,5-Dimethylpyridin-2-yl)piperazine

Product 1

HCID 71252880HCID 71252880, compoundYield 104.4%

Procedure

Using (S)-4-(1-methanesulfonylaminoethyl)benzoic acid (146 mg) described in Preparation Example 73 and 1-(3,5-dimethylpyridin-2-yl)piperazine (126 mg) described in Preparation Example 79 and by the reaction and treatment in the same manner as in Example 87, the title compound (261 mg) was obtained.

Workup

  1. customdescribed in Preparation Example 79 and by the reaction and treatment in the same manner as in Example 87

Sources & evidence

ORD record
ord-6ae30f2a7b194883a343ae4b414a0d6f
Source dataset
uspto-grants-2014_08
Patent number
US08816079B2

Reaction notes

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