Acetamide → HCID 71253064, compound

HRID 2411823Notes

Reaction equation

HRID 2411823 reaction equation
Br[C:2]1[CH:7]=[CH:6][C:5]([C:8]([N:10]2[CH2:15][CH2:14][N:13]([C:16]3[CH:21]=[CH:20][C:19]([CH3:22])=[CH:18][C:17]=3[CH3:23])[CH2:12][CH2:11]2)=[O:9])=[C:4]([S:24]([CH3:27])(=[O:26])=[O:25])[CH:3]=1.[C:28]([NH2:31])(=[O:30])[CH3:29]>>[CH3:23][C:17]1[CH:18]=[C:19]([CH3:22])[CH:20]=[CH:21][C:16]=1[N:13]1[CH2:14][CH2:15][N:10]([C:8]([C:5]2[CH:6]=[CH:7][C:2]([NH:31][C:28](=[O:30])[CH3:29])=[CH:3][C:4]=2[S:24]([CH3:27])(=[O:26])=[O:25])=[O:9])[CH2:11][CH2:12]1

Participants

3

Reactant 2

HCID 178AcetamideHCID 58484856(4-Bromo-2-methanesulfonylphenyl)[4-(2,4-dimethylphenyl)piperazin-1-yl]methanone

Product 1

HCID 71253064HCID 71253064, compoundYield 10.8%

Procedure

Using (4-bromo-2-methanesulfonylphenyl)[4-(2,4-dimethylphenyl)piperazin-1-yl]methanone (526 mg) described in Preparation Example 110 and acetamide (75.7 mg) and by the reaction and treatment in the same manner as in Example 1, the title compound (54 mg) was obtained.

Sources & evidence

ORD record
ord-462beacc8f9e4398a05ab39bc75b8d0a
Source dataset
uspto-grants-2014_08
Patent number
US08816079B2

Reaction notes

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